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Sorafenat 200mg: Buy Sorafenib 200 mg tab price in UK & USA

· Anti Cancer

Sorafenat is the newest drug, a multi-kinase inhibitor with antitumor activity.
Active ingredient - Sorafenib 200 mg tab price, has a suppressible effect on tumor growth. Sorafenat is used in the treatment of metastatic renal cell and hepatocellular carcinoma. Studies have established the effectiveness of the drug - Sorafenat can reduce the risk of further progression of the disease with such diagnoses as primary liver cancer or hepatocellular carcinoma. The drug is used in more than 100 countries around the world. The use of Sorafenat is also relevant as a substitute for interferon-alpha and interleukin therapy in those patients for whom this treatment is contraindicated or did not help due to various factors. Sorafenat can also be used as a 1st line therapy for inoperable and locally advanced and disseminated kidney cancer, as well as a 2nd line for the treatment of non-cell-cell kidney cancer and tumors

 

Drug indications:
 

- metastatic renal cell carcinoma;
- hepatocellular carcinoma

 

Method of application:
 

Inside. The recommended dose is 800 mg / day. Sorafenat can be taken on an empty stomach and with food. It is desirable that the food does not contain a large amount of fat, because it helps to reduce the bioavailability of sorafenib.
Treatment with Sorafenat is discontinued if the clinical effect disappears.
The drug should also be discontinued if an unacceptable toxic effect occurs during the treatment with Sorafenat.
A dose reduction of up to 400 mg / day may be required if various side effects occur.
There are no data on the use of Sorafenat in patients with severely impaired liver function and in patients who are on hemodialysis.

 

Special instructions:
 

Sorafenat treatment is carried out under the supervision of a physician who has experience in antitumor therapy.
During the entire course of Sorafenat administration, monitoring of peripheral blood parameters (leukocyte formula and platelets) is required.
The most common adverse reactions when taking Sorafenat were skin reactions, especially in the limbs, and rash. As a rule, they were of the 1st or 2nd degree of severity, and their manifestation was noted during the first 6 weeks of therapy. Such adverse reactions can be stopped by lowering the dose of Sorafenat, appropriate treatment. With repeated repetition of these side effects, as well as in the case of their severe manifestation, treatment with sorafenib cannot be continued.
During the course of taking Sorafenat, it is necessary to regularly monitor the patient's blood pressure to prevent the development of arterial hypertension. If necessary, prescribe antihypertensive drugs. With the development of severe or persistent hypertension can be abolished.
When prescribing Sorafenat price in USA in combination with warfarin, prothrombin time, INR and clinical signs of bleeding should be regularly determined.
The appointment or resumption of therapy with the use of Sorafenat in the case of surgical interventions requires a special solution, which should be based on an assessment of the adequacy of wound healing.
Therapy with the use of Sorafenat can be stopped if there is evidence of ischemia and / or myocardial infarction, perforation of the gastrointestinal tract.
Sorafenat should be used with caution in combination with drugs that are metabolized / excreted mainly with the participation of UGT1A1 (irinotecan), as well as with docetaxel.
In patients at risk of impaired renal function, monitoring of water and electrolyte balance is necessary.